| Country | Time | Match | Home | Away | Tip | Result |
| ESP | 2021-01-13 |
Granada
VS Osasuna |
Granada | Osasuna | 1X | (2:0) |
| EGY | 2021-01-13 |
Al Ahly
VS El-Entag El-Harby |
Al Ahly | El-Entag El-Harby | W1 | (4:1) |
| GER | 2021-01-12 |
Eintracht Braunschweig
VS Fortuna Düsseldorf |
Eintracht Braunschweig | Fortuna Düsseldorf | 2X | (0:0) |
| ESP | 2021-01-12 |
Sporting Gijón
VS Fuenlabrada |
Sporting Gijón | Fuenlabrada | TU HT(1.5) | (1:0) |
| GRE | 2021-01-12 |
Lamia
VS AEK Athens |
Lamia | AEK Athens | W2 | (0:1) |
| GRE | 2021-01-12 |
PAS Giannina
VS Aris Thessaloniki |
PAS Giannina | Aris Thessaloniki | 2X | (0:0) |
| TUR | 2021-01-11 |
Erzurum BB
VS Fenerbahce |
Erzurum BB | Fenerbahce | 2X | (0:3) |
| ESP | 2021-01-11 |
Espanyol
VS Castellón |
Espanyol | Castellón | 1X | (2:0) |
| ITA | 2021-01-11 |
Juventus
VS Sassuolo |
Juventus | Sassuolo | 1X | (3:1) |
| NED | 2021-01-11 |
Ajax Amsterdam
VS PSV Eindhoven |
Ajax Amsterdam | PSV Eindhoven | BTS | (2:2) |
| ENG | 2021-01-10 |
Chelsea
VS Morecambe |
Chelsea | Morecambe | TO (1.5) | (4:0) |
| ENG | 2021-01-10 |
Manchester City
VS Birmingham |
Manchester City | Birmingham | W1 | (3:0) |
| ENG | 2021-01-10 |
Manchester United
VS Watford |
Manchester United | Watford | 1X | (1:0) |
| ITA | 2021-01-10 |
AC Milan
VS Torino |
AC Milan | Torino | 1X | (2:0) |
| ESP | 2021-01-10 |
Granada
VS Barcelona |
Granada | Barcelona | 2X | (0:4) |
| GRE | 2021-01-10 |
Panetolikos
VS Olympiacos |
Panetolikos | Olympiacos | W2 | (1:2) |
| NED | 2021-01-09 |
Almería
VS Eindhoven |
Almería | Eindhoven | 1X | (0:0) |
| FRA | 2021-01-09 |
Dunkerque
VS Troyes |
Dunkerque | Troyes | 2X | (0:0) |
| POR | 2021-01-09 |
Benfica
VS Tondela |
Benfica | Tondela | W1 | (2:0) |
| POR | 2021-01-09 |
Nacional (PT)
VS Sporting |
Nacional (PT) | Sporting | 2X | (0:2) |