| Country | Time | Match | Home | Away | Tip | Result |
| ESP | 2020-12-23 |
Huesca
VS Levante |
Huesca | Levante | 2X | (1:1) |
| GER | 2020-12-23 |
1. FC Köln
VS VfL Osnabrück |
1. FC Köln | VfL Osnabrück | 12 | (1:0) |
| ESP | 2020-12-22 |
Tenerife
VS Girona |
Tenerife | Girona | TU 2.5 | (2:0) |
| ENG | 2020-12-22 |
Chelsea
VS West Ham United |
Chelsea | West Ham United | TO 1.5 | (3:0) |
| ENG | 2020-12-22 |
Burnley
VS Wolverhampton |
Burnley | Wolverhampton | BTS | (2:1) |
| ITA | 2020-12-22 |
Salernitana
VS Virtus Entella |
Salernitana | Virtus Entella | 1X | (2:1) |
| ENG | 2020-12-22 |
Chelsea
VS West Ham United |
Chelsea | West Ham United | 1X | (3:0) |
| ROU | 2020-12-22 |
FCSB
VS Sepsi Sf. Gheorghe |
FCSB | Sepsi Sf. Gheorghe | 1X | (1:1) |
| GRE | 2020-12-22 |
AEK Athens
VS Volos |
AEK Athens | Volos | TO 1.5 | (2:2) |
| DEN | 2020-12-21 |
AC Horsens
VS Brøndby IF |
AC Horsens | Brøndby IF | TO 1.5 | (1:2) |
| ITA | 2020-12-21 |
Atalanta
VS Roma |
Atalanta | Roma | TO 1.5 | (4:1) |
| GER | 2020-12-20 |
SC Freiburg
VS Hertha BSC |
SC Freiburg | Hertha BSC | TO 1.5 | (4:1) |
| ITA | 2020-12-20 |
Internazionale Milan
VS Spezia |
Internazionale Milan | Spezia | W1 | (2:1) |
| NED | 2020-12-20 |
ADO Den Haag
VS Ajax Amsterdam |
ADO Den Haag | Ajax Amsterdam | W2 | (2:4) |
| AUT | 2020-12-20 |
Red Bull Salzburg
VS Wolfsberger |
Red Bull Salzburg | Wolfsberger | TO 2.5 | (2:3) |
| GRE | 2020-12-20 |
Olympiacos
VS AEL Larissa |
Olympiacos | AEL Larissa | W1 | (5:1) |
| ENG | 2020-12-20 |
Newcastle United
VS Fulham |
Newcastle United | Fulham | 1X | (1:1) |
| NED | 2020-12-20 |
RKC Waalwijk
VS PSV Eindhoven |
RKC Waalwijk | PSV Eindhoven | TO 2.5 | (1:4) |
| HUN | 2020-12-20 |
Ferencvaros TC
VS Budafoki MTE |
Ferencvaros TC | Budafoki MTE | W1 | (2:1) |
| NED | 2020-12-20 |
VVV-Venlo
VS FC Twente |
VVV-Venlo | FC Twente | 2X | (1:2) |