| Country | Time | Match | Home | Away | Tip | Result |
| ESP | 2021-02-22 |
Athletic Bilbao
VS Villarreal |
Athletic Bilbao | Villarreal | 15 min X | (1:1) |
| ESP | 2021-02-22 |
Real Sociedad
VS Alavés |
Real Sociedad | Alavés | TO (1.5) | (4:0) |
| GER | 2021-02-21 |
Hertha BSC
VS RB Leipzig |
Hertha BSC | RB Leipzig | TO (1.5) | (0:3) |
| GER | 2021-02-21 |
Hertha BSC
VS RB Leipzig |
Hertha BSC | RB Leipzig | TO (2.5) | (0:3) |
| ENG | 2021-02-21 |
Aston Villa
VS Leicester City |
Aston Villa | Leicester City | 15 min X | (1:2) |
| FRA | 2021-02-21 |
Nice
VS Metz |
Nice | Metz | TO (1.5) | (1:2) |
| ITA | 2021-02-21 |
AC Milan
VS Internazionale Milan |
AC Milan | Internazionale Milan | TO (1.5) | (0:3) |
| GER | 2021-02-21 |
Bayern Munchen II
VS Viktoria Köln |
Bayern Munchen II | Viktoria Köln | TO HT(0.5) | (0:1) |
| GRE | 2021-02-21 |
Apollon Larisas
VS Chania-Kissamikos |
Apollon Larisas | Chania-Kissamikos | TU (3.5) | (1:0) |
| POR | 2021-02-21 |
Leixoes
VS Estoril |
Leixoes | Estoril | TU (3.5) | (0:1) |
| ENG | 2021-02-21 |
Liverpool
VS Everton |
Liverpool | Everton | TU (3.5) | (0:2) |
| GER | 2021-02-21 |
FC Schalke 04
VS Borussia Dortmund |
FC Schalke 04 | Borussia Dortmund | TO (2.5) | (0:4) |
| FRA | 2021-02-21 |
Nantes
VS Marseille |
Nantes | Marseille | TO (1.5) | (1:1) |
| FRA | 2021-02-21 |
Nantes
VS Marseille |
Nantes | Marseille | TO (1.5) | (1:1) |
| ESP | 2021-02-21 |
Atlético Madrid
VS Levante |
Atlético Madrid | Levante | TU (3.5) | (0:2) |
| ENG | 2021-02-21 |
Burnley
VS West Bromwich Albion |
Burnley | West Bromwich Albion | 15 min X | (0:0) |
| ENG | 2021-02-21 |
Norwich
VS Rotherham |
Norwich | Rotherham | 1X | (1:0) |
| ENG | 2021-02-21 |
Stoke
VS Luton |
Stoke | Luton | 1X | (3:0) |
| ENG | 2021-02-21 |
Reading
VS Middlesbrough |
Reading | Middlesbrough | TO (1.5) | (0:2) |
| ENG | 2021-02-21 |
Burnley
VS West Bromwich Albion |
Burnley | West Bromwich Albion | TU (3.5) | (0:0) |