| Country | Time | Match | Home | Away | Tip | Result |
| ENG | 2021-02-21 |
Burton
VS Sunderland |
Burton | Sunderland | W2 | (0:3) |
| GER | 2021-02-20 |
Eintracht Frankfurt
VS FC Bayern Munich |
Eintracht Frankfurt | FC Bayern Munich | TO (2.5) | (2:1) |
| ESP | 2021-02-20 |
Elche
VS Eibar |
Elche | Eibar | TU (3.5) | (1:0) |
| ESP | 2021-02-20 |
Elche
VS Eibar |
Elche | Eibar | 15 min X | (1:0) |
| ESP | 2021-02-20 |
Elche
VS Eibar |
Elche | Eibar | TU HT(1.5) | (1:0) |
| GER | 2021-02-20 |
1. FC Saarbrücken
VS 1860 Munchen |
1. FC Saarbrücken | 1860 Munchen | TO HT(0.5) | (1:0) |
| ENG | 2021-02-20 |
Southampton
VS Chelsea |
Southampton | Chelsea | 2X | (1:1) |
| ENG | 2021-02-20 |
Southampton
VS Chelsea |
Southampton | Chelsea | 15 min X | (1:1) |
| FRA | 2021-02-20 |
Saint-Étienne
VS Stade de Reims |
Saint-Étienne | Stade de Reims | TO (1.5) | (1:1) |
| ESP | 2021-02-20 |
Ponferradina
VS Mirandés |
Ponferradina | Mirandés | TU (3.5) | (1:0) |
| GER | 2021-02-20 |
Arminia Bielefeld
VS VfL Wolfsburg |
Arminia Bielefeld | VfL Wolfsburg | 2X | (0:3) |
| NED | 2021-02-20 |
Willem II
VS FC Utrecht |
Willem II | FC Utrecht | 2X | (0:6) |
| SUI | 2021-02-20 |
Wil
VS Grasshoppers |
Wil | Grasshoppers | 2X | (1:1) |
| ROU | 2021-02-20 |
U Craiova
VS FC Hermannstadt |
U Craiova | FC Hermannstadt | TU (3.5) | (1:0) |
| NED | 2021-02-20 |
Dordrecht
VS NAC Breda |
Dordrecht | NAC Breda | W2 | (2:3) |
| CZE | 2021-02-20 |
Jablonec
VS Mladá Boleslav |
Jablonec | Mladá Boleslav | 1X | (1:1) |
| EUR | 2021-02-19 |
Lille
VS Ajax Amsterdam |
Lille | Ajax Amsterdam | TO (1.5) | (1:2) |
| EUR | 2021-02-19 |
Lille
VS Ajax Amsterdam |
Lille | Ajax Amsterdam | TO (1.5) | (1:2) |
| EUR | 2021-02-19 |
Maccabi Tel Aviv
VS Shakhtar Donetsk |
Maccabi Tel Aviv | Shakhtar Donetsk | 2X | (0:2) |
| EUR | 2021-02-19 |
Granada
VS Napoli |
Granada | Napoli | TO (1.5) | (2:0) |