| Country | Time | Match | Home | Away | Tip | Result |
| RSA | 2021-02-18 |
Mamelodi Sundowns
VS Baroka |
Mamelodi Sundowns | Baroka | 1X | (2:0) |
| EUR | 2021-02-17 |
Barcelona
VS Paris Saint German |
Barcelona | Paris Saint German | BTS | (1:4) |
| NED | 2021-02-17 |
Telstar
VS NAC Breda |
Telstar | NAC Breda | TO (2.5) | (1:2) |
| ENG | 2021-02-17 |
Stoke
VS Sheffield Wed |
Stoke | Sheffield Wed | TU (3.5) | (1:0) |
| ENG | 2021-02-17 |
Barnet
VS FC Halifax |
Barnet | FC Halifax | TO (1.5) | (2:1) |
| ENG | 2021-02-17 |
Gillingham
VS Peterborough |
Gillingham | Peterborough | TO (1.5) | (1:3) |
| ENG | 2021-02-16 |
Chelsea
VS Newcastle United |
Chelsea | Newcastle United | 1X | (2:0) |
| ENG | 2021-02-16 |
West Ham United
VS Sheffield United |
West Ham United | Sheffield United | 1X | (3:0) |
| ROU | 2021-02-16 |
FC Botosani
VS Gaz Metan Medias |
FC Botosani | Gaz Metan Medias | 1X | (2:1) |
| BUL | 2021-02-15 |
Ludogorets Razgrad
VS Etar Veliko |
Ludogorets Razgrad | Etar Veliko | W1 | (6:0) |
| TUR | 2021-02-15 |
Genclerbirligi
VS Besiktas |
Genclerbirligi | Besiktas | 2X | (0:3) |
| ENG | 2021-02-15 |
Everton
VS Fulham |
Everton | Fulham | 1X | (0:2) |
| DEN | 2021-02-15 |
FC Midtjylland
VS AC Horsens |
FC Midtjylland | AC Horsens | W1 | (1:0) |
| DEN | 2021-02-15 |
Lyngby BK
VS Brøndby IF |
Lyngby BK | Brøndby IF | 2X | (0:4) |
| TUR | 2021-02-14 |
Galatasaray
VS Kasimpasa |
Galatasaray | Kasimpasa | W1 | (2:1) |
| ESP | 2021-02-14 |
Barcelona
VS Alavés |
Barcelona | Alavés | W1 | (5:1) |
| ENG | 2021-02-14 |
Manchester City
VS Tottenham |
Manchester City | Tottenham | 1X | (3:0) |
| GER | 2021-02-14 |
1. FC Union Berlin
VS FC Schalke 04 |
1. FC Union Berlin | FC Schalke 04 | 1X | (0:0) |
| FRA | 2021-02-14 |
Paris Saint German
VS Nice |
Paris Saint German | Nice | W1 | (2:1) |
| ESP | 2021-02-14 |
Sevilla
VS Huesca |
Sevilla | Huesca | 1X | (1:0) |